个人简介
老五白菜网副教授，博士生导师
围绕着修饰核酸，包括表观遗传学修饰以及人工修饰的核酸，在核酸的测序、检测、调控方面取得了一些成果，开发出针对特定修饰碱基的测序方法，发现了一些比较好的检测方法和调控手段，下一步我们希望在现有基础上利用这些研究方法和手段，能够在基因层面上对相关的生物功能和机理的研究取得一些突破，并真正将检测技术应用于临床疾病的早期检测和诊断。承担项目与课题1. 国家自然科学基金面上项目(2023)，基于邻近诱导化学的表观遗传修饰核酸结合蛋白的标记方法；2. 国家自然科学基金面上项目(2016)， DNA中甲基、羟甲基、醛基胞嘧啶多位点检测及胞嘧啶羟甲基修饰的方法研究；3. 国家自然科学基金青年基金(2014)，新型可诱导DNA甲基转移酶和组蛋白甲基转移酶抑制剂的设计合成,构效关系和活性研究。
教育经历
2000.09-2004.06 老五白菜网 大学本科
2004.09-2010.07 老五白菜网 博士研究生
2007.09-2008.09 格勒诺布尔一大化学系 联合培养研究生
工作经历
2009.01-2010.01 弗吉尼亚大学化学系 访问学者
2013.04-至今 老五白菜网 副教授
研究方向
开发修饰碱基测序方法、小分子探针的开发、核酸表观遗传修饰的检测
代表成果
1.Zhang Y.; Yan S.; Chen Z.; Jiang X.; Rao S.; Jiang Z.; Qin S.; Zhou X.; Du Y. D ; Visually Intracellular Detection of Telomerase Activity Based on DNA Strand Displacement Reaction and Gold Nanoparticle Labeling, Chinese Journal of Chemistry, 2022, 40: 693-698
2.Yajun Zhang; Qiuyang Zhang; Xiaocheng Weng; Yuhao Du Y ; Xiang Zhou ; NEase-based amplificat ion for detection of miRNA, multiple miRNAs and circRNA, Analytica Chimica Acta, 2021, 1145: 52-58
3.Yaqian Liu, Xiong Zhang, Min Liu, Fa Xu, Qiuyang Zhang, Yajun Zhang, Xiaocheng Weng, Songmei Liu, Yuhao Du*, Xiang Zhou, Direct detection of circRNA in real samples using reverse transcription-rolling circle amplification, Anal. Chim. Acta., 2020, 1101: 169-175
4. Min Liu, Wu Fan, Yuhao Du*, Xiang Zhou*, Specific stabilization of DNA G-quadruplex structures with a chemically modified complementary probe，Bioorg. Med. Chem. 2019, 27, 1962
5. Yinong Liu, Cheng Zhong, Zhiyong He, Shuang Rao, Haomiao Su, Fan Wu, Boshi Fu, Jinjun Wu, Yanyan Song, Yuhao Du*, and Xiang Zhou* . Sensors and Actuators B, 2018, 255, 2151
6.Zhiyong He, Chen, Yuqi Chen, Yafen Wang, Jiaqi Wang, Jing Mo, Boshi Fu, Zijing Wang, Xiang Zhou*, Yuhao Du*, A rapidly photo-activatable light-up fluorescent nucleoside and its application in DNA base variation sensing, Chem. Commun, 2016, 52, 8545
7.Shuang Rao, Yuqi Chen, Tingting Hong, Zhiyong He, Shan Guo, Han Lai, Ge Guo, Yuhao Du*，Xiang Zhou*，Simultaneous and Sensitive Detection of Multisite 5-Methylcytosine Including Non-CpG Sites at Single-5mC-Resolution. Anal. Chem, 2016, 88, 10547.
8.Yuhao Du*, Xiang Zhou*, Targeting non-B-form DNA in living cells. Chem. Rec, 2013, 371
9.Yuhao Du, Charles Hendrick, Krysta Frye, Lindsay Comstock*, Fluorescent DNA labeling by N-mustard analogues of S-adenosyl-L-methionine. ChemBioChem, 2012, 13, 2225
10.Mark Turlington, Yuhao Du, Samuel G Ostrum, Wren Vishaka, Tony Lin, Michal Sabat，Lin Pu*, From highly enantioselective catalytic reaction of 1,3-diynes with aldehydes to facile asymmetric synthesis of polycyclic compounds. J. Am. Chem. Soc., 2011, 133, 11780
