个人简介

周翔，现任老五白菜网教授，博士生导师；现任老五白菜网第三届学术委员会副主任。2021年11月，当选中国科学院院士； 2022年5月， 当选中国化学会分子医学专业委员会副主任委员；2022年7月，当选2021年中国化学会会士。

教育经历

1982.09-1986.06       老五白菜网化学系     大学本科

1986.09-1989.07       老五白菜网化学系     硕士研究生

1993.01-1996.05       香港中文大学化学系  博士研究生

工作经历

1989.07-1992.12      老五白菜网化学系     助教，讲师

1996.10-1998.10      弗吉尼亚大学化学系   博士后

1998.11-2001.05      马里兰大学化学和生物化学系 博士后

2001.05-至今          老五白菜网  教授，博导

研究方向

长期致力于核酸化学生物学的研究,主要研究方向为:小分子对核酸结构的识别及其功能调控研究、基于核酸化学技术在疾病诊疗中的应用。通过小分子对核酸结构的识别和功能调控，开发核酸靶向药物分子和重大疾病诊断技术，取得了系统的、在国际上有影响力的创新性成果,推进了核酸化学生物学研究发展。

代表成果

1.Wang, Y. F., Han, S. Q., Ran, R. X., Li, A. L., Liu, H. Y., Liu, M. J., Duan, Y. W., Zhang, X., Zhao, Z. G., Song, S. H., Weng, X. C.,* Liu, S. M.,* Zhou, X. * , A longitudinal sampling study of transcriptomic andepigenetic profiles in patients withthrombocytopenia syndrome,Nat Commun.,2021,12: 5629.

2.Wang, Y. F., Zhang, X., Liu. H. and Zhou, X. *,  Chemical methods and advanced sequencingtechnologies for deciphering mRNA modifications,Chem. Soc. Rev.,2021, 50, 13481.

3.Wang, Y. F., Zhang, X., Han, S. Q., Yang, W., Chen, Z. G., Wu, F., Liu, J. Z., Weng, X. C.*, Zhou, X.*, Base Resolution Analysis of Deoxyuridine at the Genome Scale Based on the Artificial Incorporation Modified Nucleobase, ACS Cent. Sci.,2021, 7, 973.(Cover)

4.Jiang, Z. R., Wang, C., Wu, Z. X., Chen, K., Yang, W., Deng, H. X.*, Song, H.,* and Zhou, X.* Enzymatic deamination of the epigenetic nucleoside N6-methyladenosine regulates gene expression,Nucleic Acids Res.,2021,49,12048.

5.Su, H. M., Xu, J. L., Chen, Y. Q., Wang, Q., Lu, Z. A., Chen, Y. G., Chen, K., Han, S. Q., Fang, Z. T., Wang, P., Yuan, B. F., and Zhou, X.*, Photoactive G Quadruplex Ligand Identifies MultipleG Quadruplex Related Proteins with Extensive Sequence Tolerance in the Cellular Environment,J. Am. Chem. Soc.,2021, 143, 1917.

6.Xu, J. L., Huang, H. Y., and Zhou, X.*, G‑Quadruplexes in Neurobiology and Virology: Functional Rolesand Potential Therapeutic ApproachesJACS Au 2021, 1, 2146.

7.Weng, X. C., Gong, J., Chen, Y., Wu, T., Wang, F., Yang, S. X., Yuan, Y. S., Luo, G. Z., Chen, K., Hu, L. L., Ma, H. H., Wang, P. L., Zhang, Q. F. C.*, Zhou, X.*, He, C.*, Keth-seq for transcriptome-wide RNA structure mapping.Nat. Chem Biol.,2020, 16, 489.

8.Peng, S., Bie, B. L., Jia, H. N., Tang, H., Zhang, X., Sun, Y. Q., Wei, Q., Wu, F., Yuan, Y. S., Deng, H. X.*,Zhou, X.*, Efficient Separation of Nucleic Acids with Different Secondary Structures by Metal–Organic Frameworks.J. Am. Chem. Soc.,2020, 142, 11, 5049.

9.Wang, S. R., Wu, L. Y., Huang, H. Y., Xiong, W., Liu, J., Wei, L., Yin, P., Tian, T.*, Zhou, X.*, Conditional control of RNA-guided nucleic acid cleavage and gene editing.Nat Commun.,2020, 11:91.

10.Chen, Y. Q., Wu, F., Chen, Z. G., He, Z. Y., Wei, Q., Zeng, W. W., Chen, K., Xiao, F., Yuan, Y. S., Weng, X. C., Zhou, Y., Zhou, X.*, Acrylonitrile-Mediated Nascent RNA Sequencing for Transcriptome-Wide Profiling of Cellular RNA Dynamics.Adv. Sci.,2020, 7:1900997.